Nexavar Side Effects

Some side effects of Nexavar might not be reported. Always talk to your physician or health care specialist for medical health advice. You may even report side effects towards the Food and drug administration.

 

For that Consumer

Is applicable to sorafenib: dental tablet

Together with its needed effects, sorafenib (the active component found in Nexavar) could cause some undesirable effects. Although not every one of these side effects can happen, when they occur they might need medical assistance.

Seek advice from your physician immediately if the following side effects occur while taking sorafenib:

More prevalent

• Abdominal or stomach discomfort


• bleeding nicotine gums


• bloatedness from the abdomen or stomach


• bloodstream within the urine or stools


• blurred vision


• clay-colored stools


• paying bloodstream


• dark urine


• difficulty breathing or ingesting


• lightheadedness


• headache


• elevated menstrual flow or vaginal bleeding


• light-colored stools


• vomiting and nausea


• anxiety


• nosebleeds


• paralysis


• pounding within the ears


• prolonged bleeding from cuts


• red-colored or black, tarry stools


• red-colored or brownish urine


• slow or fast heartbeat


• vomiting of bloodstream


• yellow eyes or skin

Less frequent

• Bone discomfort


• chest discomfort or discomfort


• chills


• sticky skin


• confusion


• constipation


• withdrawal leading to convulsions (seizures)


• cough


• decreased urine production


• depressed mood


• difficulty moving


• dry hair and skin


• enlarged pupils


• feeling cold


• fever


• hair thinning


• hearing problems


• hives


• hoarseness or husky voice


• elevated sensitivity from the eyes to light


• elevated sweating, possibly with fever or cold


• elevated thirst


• heartburn


• itchiness


• joint discomfort


• appetite loss


• back or side discomfort


• muscle cramps and stiffness


• muscle discomfort


• discomfort or discomfort within the arms, jaw, back, or neck


• painful or difficult peeing


• pains within the stomach, side, or abdomen, possibly radiating towards the back


• pale skin


• pinpoint red-colored spots onto the skin


• reddening of your skin, especially round the ears


• ringing, buzzing, or any other inexplicable noise within the ears that continues


• severe chest discomfort


• severe headache


• a sore throat


• sores, stomach problems, or whitened spots around the lips or perhaps in the mouth


• stiff or sore neck


• stomach discomfort or upset


• sweating


• swelling from the ankles or hands


• swelling from the eyes, face, or within the nose


• inflamed glands


• inflamed joints


• trouble breathing with effort


• uncomfortable breath odor


• unusual bleeding or bruising


• unusual fatigue or weakness


• putting on weight

Incidence unfamiliar

• Blistering, peeling, or helping to loosen of your skin


• diarrhea


• large, hive-like swelling evidently, eyelids, lips, tongue, throat, hands, legs, ft, or reproductive organs


• red-colored lesions on the skin, frequently having a crimson center


• red-colored, inflammed eyes

Some side effects of sorafenib can happen that tend not to need medical assistance. These side effects might have to go away throughout treatment as the body changes towards the medicine. Also, your healthcare professional may have the ability to let you know about methods to prevent or reduce a few of these side effects. Seek advice from your healthcare professional if the following side effects continue or are annoying or you have questions regarding them:

More prevalent

• Blistering, peeling, redness, and/or swelling from the palms from the hands or bottom from the ft


• burning, tingling, numbness or discomfort in the possession of, arms, ft, or legs


• numbness, discomfort, tingling, or unusual sensations in palms from the hands or bottom from the ft


• sensation of tingling


• stabbing discomfort


• loss from the hair


• rigidity within the chest


• weight reduction

Less frequent

• Acidity or sour stomach


• acne


• belching


• blistering, peeling, or helping to loosen of your skin


• burning perspective of chest or stomach


• burning, itchiness, and discomfort in hairy areas


• cracked lips


• cracks within the skin


• decreased appetite


• decreased curiosity about intercourse


• discouragement


• xerostomia


• fainting


• sense of warmth


• feeling sad or empty


• eliminating or red-colored skin


• gas


• general sense of discomfort or illness


• acid reflux


• lack of ability to possess or keep a harder erection


• rise in heartbeat


• irritability


• lack or lack of strength


• wooziness


• reduction in sexual ability, desire, drive, or performance


• lack of capability to use or understand speech or language


• lack of warmth in the body


• lack of interest or pleasure


• mouth discomfort


• pus at the bottom from the hair


• rapid breathing


• red-colored face, neck, arms, and from time to time, upper chest


• red-colored, inflamed skin


• runny nose


• scaly skin


• shivering


• skin rash that's encrusted, scaly, and oozing


• sunken eyes


• swelling from the breasts or breast tenderness both in males and ladies


• swelling or inflammation from the mouth


• tenderness within the abdomen


• thirst


• trouble focusing


• sleep problems


• abnormally warm skin


• wrinkled skin

For Health care Professionals

Is applicable to sorafenib: dental tablet

Intestinal

Intestinal (GI) side effects including diarrhea (43%), elevated lipase (41%), elevated amylase (30%), nausea (23%), anorexia (16%), vomiting (16%), and constipation (15%) happen to be reported. Common side effects have incorporated mucositis, stomatitis, (including xerostomia and glossodynia), dyspepsia, and dysphagia. Uncommon side effects have incorporated pancreatitis, GI reflux, and gastritis. Additionally, GI perforation continues to be reported in under 1% of patients receiving sorafenib (the active component found in Nexavar) and never always connected with apparent intra- abdominal tumor.

Dermatologic

Dermatologic side effects including rash/desquamation (40%), Hands-feet skin reaction (30%), alopecia (27%), pruritus (19%), and dried-out skin (11%) happen to be reported. Common side effects have incorporated erythema. Common side effects have incorporated exfoliative dermatitis, acne, and eliminating. Scalp dysesthesia and subungual splinter hemorrhages (indicated by straight black or red-colored lines underneath the nails) happen to be reported. Uncommon side effects have incorporated folliculitis, eczema, Stevens-Manley syndrome, and erythema multiforme. Three installments of keratoacanthomas and 2 installments of sorafenib-caused eruptive melanocytic lesions happen to be reported. Postmarketing reviews of Stevens-Manley syndrome and toxic skin necrolysis happen to be received.

Endocrine

Endocrine side effects have incorporated hyperthyroidism.

Cardiovascular

Cardiovascular side effects including hypertension (17%), angioedema, and congestive heart failure happen to be reported. Uncommon side effects have incorporated hypertensive crisis, myocardial ischemia, and/or infarction. Cardiac failure, thromboembolism, and arrhythmia happen to be reported rarely.

Hematologic

Hematologic side effects including Hypoalbuminemia (49%), hemorrhage (15%) (i.e., intestinal, respiratory system and barely cerebral hemorrhage) happen to be reported. Common side effects have incorporated anemia and thrombocytopenia. Uncommon side effects have incorporated abnormal worldwide stabilized ratio (INR) results. Installments of erythrocytosis are also reported.

Respiratory system

Respiratory system side effects including dyspnea (14%) and cough (13%) happen to be reported. Common side effects have incorporated hoarseness. Uncommon side effects have incorporated rhinorrhea and interstitial lung disease-like occasions.

Central nervous system

Central nervous system side effects including physical neuropathy (13%) and headache (10%) happen to be reported. Common side effects have incorporated tinnitus. Cerebral hemorrhage, transient ischemic attack, and reversible posterior leukoencephalopathy are also reported rarely.

Bone and joint

Bone and joint side effects including joint discomfort (10%) happen to be reported. Common side effects have incorporated arthralgia and myalgia. Postmarketing reviews of rhabdomyolysis and osteonecrosis from the jaw happen to be received.

Immunologic

Immunologic side effects have very generally incorporated leukopenia and lymphopenia. Common side effects have incorporated neutropenia.

Hypersensitivity

Hypersensitivity side effects including skin responses and urticaria happen to be reported. Postmarketing reviews of angioedema and anaphylactic reaction happen to be received.

Metabolic

Metabolic side effects including hypocalcemia, weight reduction (10%), transient increases in transaminases, and hypophosphatemia happen to be generally reported. Uncommon side effects have incorporated lack of fluids, hyponatremia, hypokalemia, transient increases in alkaline phosphatase, elevated bilirubin (including jaundice), and thyroid problems.

Psychological

Psychological side effects have generally incorporated depression.

Genitourinary

Genitourinary side effects have generally incorporated erection dysfunction. Uncommon side effects have incorporated gynecomastia and proteinuria.

Kidney

Kidney side effects including acute kidney failure and nephrotic syndrome happen to be reported rarely.

Hepatic

Hepatic side effects including liver disorder happen to be reported in a minimum of 10% of patients. Drug-caused hepatitis, including reviews of hepatic failure and dying, continues to be reported throughout postmarketing surveillance.

Other

Other side effects including fatigue (37%) and abdominal discomfort (11%) happen to be reported. Common side effects have incorporated asthenia and discomfort (including mouth, bone, and tumor discomfort). Common side effects have incorporated decreased appetite, influenza-like illness, and pyrexia. Uncommon side effects have incorporated infection.